Publications – Thrombosis Research

2025

2025

Curtis J, Henderson DP, Zarghami M, Rashedi S, Bikdeli B. Management of antithrombotic therapy in patients undergoing dental procedures. J Thromb Haemost. 2025 Jan;23(1):47-72. doi: 10.1016/j.jtha.2024.09.022. Epub 2024 Oct 10. PMID: 39395540.

WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group; Vale CL, Godolphin PJ, Fisher DJ, Higgins JPT, McAleenan A, Spiga F, Tritschler T, de Barros E Silva PGM, Berg DD, Berger JS, Berry LR, Bikdeli B, Blondon M, Bohula EA, Cattaneo M, Colombo R, Coluccio V, DeSancho MT, Farkouh ME, Fuster V, Girardis M, Hochman JS, Jensen TP, Jha V, Jüni P, Kirtane AJ, Lawler P, Le Gal G, Lecumberri R, Lentz SR, Lopes RD, Lorenzi E, Marietta M, Miranda CH, Morici N, Morpeth SC, Morrow DA, McQuilten ZK, Muñoz-Rivas N, Neal MD, Pant S, Parikh SA, Perepu U, Sadeghipour P, Sethi S, Sholzberg M, Spyropoulos AC, Stone GW, Talasaz AH, Tong S, Totterdell J, Venkatesh B, Wu MA, Zarychanski R, Zuily S, Viry J, Rylance J, Adhikari NKJ, Diaz JV, Marshall JC, Sterne JAC, Murthy S. Anticoagulation Among Patients Hospitalized for COVID-19 : A Systematic Review and Prospective Meta-analysis. Ann Intern Med. 2025 Jan;178(1):59-69. doi: 10.7326/ANNALS-24-00800. Epub 2024 Dec 24. PMID: 39715559.

Jiménez D, Bertoletti L, Bikdeli B. Pulmonary embolism work-up in chronic obstructive pulmonary disease exacerbations: what is the best strategy for clinicians? Curr Opin Pulm Med. 2025 Mar 1;31(2):175-181. doi: 10.1097/MCP.0000000000001130. Epub 2024 Oct 23. PMID: 39469884.

Bikdeli B, Angiolillo DJ, Valgimigli M. Incorporating the Totality of Ischemic and Hemorrhagic Events: The Case of the AUGUSTUS Trial. J Am Coll Cardiol. 2025 Jan 20:S0735-1097(24)10614-6. doi: 10.1016/j.jacc.2024.11.047. Epub ahead of print. PMID: 39918471.

Bikdeli B, Khairani CD, Bejjani A, Lo YC, Mahajan S, Caraballo C, Jimenez JV, Krishnathasan D, Zarghami M, Rashedi S, Jimenez D, Barco S, Secemsky EA, Klok FA, Hunsaker AR, Aghayev A, Muriel A, Hussain MA, Appah-Sampong A, Lu Y, Lin Z, Mojibian H, Aneja S, Khera R, Konstantinides S, Goldhaber SZ, Wang L, Zhou L, Monreal M, Piazza G, Krumholz HM; PE-EHR+ Investigators. Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism. J Thromb Haemost. 2025 Feb;23(2):556-564. doi: 10.1016/j.jtha.2024.10.013. Epub 2024 Nov 4. PMID: 39505153.

Bikdeli B, Leyva H, Muriel A, Lin Z, Piazza G, Khairani CD, Rosovsky RP, Mehdipour G, O’Donoghue ML, Madridano O, Lopez-Saez JB, Mellado M, Diaz Brasero AM, Grandone E, Spagnolo PA, Lu Y, Bertoletti L, López-Jiménez L, Jesús Núñez M, Blanco-Molina Á, Gerhard-Herman M, Goldhaber SZ, Bates SM, Jimenez D, Krumholz HM, Monreal M. Sex differences in treatment strategies for pulmonary embolism in older adults: The SERIOUS-PE study of RIETE participants and US Medicare beneficiaries. Vasc Med. 2025 Feb;30(1):58-66. doi: 10.1177/1358863X241292023. Epub 2024 Nov 26. PMID: 39588564.

Zuin M, Mohanty S, Aggarwal R, Bertini M, Bikdeli B, Hamade N, Leyva H, Natale A, Boriani G, Piazza G. Trends in Sudden Cardiac Death Among Adults Aged 25 to 44 Years in the United States: An Analysis of 2 Large US Databases. J Am Heart Assoc. 2025 Jan 7;14(1):e035722. doi: 10.1161/JAHA.124.035722. Epub 2024 Dec 18. PMID: 39692035.

Lecumberri R, Ruiz-Artacho P, Trujillo-Santos J, Marcos-Jubilar M, Pérez-Pinar M, Quéré I, Claver G, Gorostidi J, Bikdeli B, Monreal M; RIETE Investigators. Impact of Baseline Thrombocytopenia on Early Outcomes in Patients With Acute Venous Thromboembolism. Am J Hematol. 2025 Mar;100(3):375-382. doi: 10.1002/ajh.27579. Epub 2025 Jan 10. PMID: 39791523; PMCID: PMC11803535.

Zarghami M, Rashedi S, Piazza G, Gerhard-Herman MD, Barnes GD, Bikdeli B. Heterogeneity in American and European Peripheral Artery Disease Guidelines on Non-statin Lipid-Lowering Therapy and Rivaroxaban. Thromb Haemost. 2025 Jan 24. doi: 10.1055/a-2510-6370. Epub ahead of print. PMID: 39775759.

Rashedi S, Keykhaei M, Sato A, Steg PG, Piazza G, Eikelboom JW, Lopes RD, Bonaca MP, Yasuda S, Ogawa H, Shizuta S, Kimura T, Okumura Y, Andreotti F, Bertoletti L, Stone GW, Mehran R, Cohen DJ, Lip GYH, Bikdeli B. Anticoagulation and Antiplatelet Therapy for Atrial Fibrillation and Stable Coronary Disease: Meta-Analysis of Randomized Trials. J Am Coll Cardiol. 2025 Jan 17:S0735-1097(25)00071-3. doi: 10.1016/j.jacc.2024.12.030. Epub ahead of print. PMID: 39918465.

Rashedi S, Bejjani A, Hunsaker AR, Aghayev A, Khairani CD, McGonagle B, Lo YC, Mahajan S, Caraballo C, Jimenez JV, Krishnathasan D, Zarghami M, Monreal M, Barco S, Secemsky EA, Klok FA, Muriel A, Hussain MA, Appah-Sampong A, Rahaghi FN, Sadeghipour P, Lin Z, Mojibian H, Aneja S, Konstantinides S, Goldhaber SZ, Wang L, Zhou L, Jimenez D, Krumholz HM, Piazza G, Bikdeli B; PE-EHR+ Investigators. Isolated subsegmental pulmonary embolism identification based on international classification of diseases (ICD)-10 codes and imaging reports. Thromb Res. 2025 Jan 20;247:109271. doi: 10.1016/j.thromres.2025.109271. Epub ahead of print. PMID: 39862754.

Bejjani A, Khairani CD, Assi A, Piazza G, Sadeghipour P, Talasaz AH, Fanikos J, Connors JM, Siegal DM, Barnes GD, Martin KA, Angiolillo DJ, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind MSV, Ruff CT, Goldhaber SZ, Krumholz HM, Mehran R, Cushman M, Eikelboom JW, Lip GYH, Weitz JI, Lopes RD, Bikdeli B. When Direct Oral Anticoagulants Should Not Be Standard Treatment: JACC State-of-the-Art Review. J Am Coll Cardiol. 2024 Jan 23;83(3):444-465. doi: 10.1016/j.jacc.2023.10.038. Erratum in: J Am Coll Cardiol. 2024 Apr 9;83(14):1351. doi: 10.1016/j.jacc.2024.02.032. PMID: 38233019.

Talasaz AH, Sadeghipour P, Ortega-Paz L, Kakavand H, Aghakouchakzadeh M, Beavers C, Fanikos J, Eikelboom JW, Siegal DM, Monreal M, Jimenez D, Vaduganathan M, Castellucci LA, Cuker A, Barnes GD, Connors JM, Secemsky EA, Van Tassell BW, De Caterina R, Kurlander JE, Aminian A, Piazza G, Goldhaber SZ, Moores L, Middeldorp S, Kirtane AJ, Elkind MSV, Angiolillo DJ, Konstantinides S, Lip GYH, Stone GW, Cushman M, Krumholz HM, Mehran R, Bhatt DL, Bikdeli B. Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease. Nat Rev Cardiol. 2024 Aug;21(8):574-592. doi: 10.1038/s41569-024-01003-3. Epub 2024 Mar 20. PMID: 38509244.

Barrios D, Durán D, Rodríguez C, Moisés J, Retegui A, Lobo JL, López R, Chasco L, Jara-Palomares L, Muriel A, Otero-Candelera R, Ruiz-Artacho P, Monreal M, Bikdeli B, Jiménez D; Air vs Oxygen for Intermediate-Risk Pulmonary Embolism Investigators. Oxygen Therapy in Patients With Intermediate-Risk Acute Pulmonary Embolism: A Randomized Trial. Chest. 2024 Mar;165(3):673-681. doi: 10.1016/j.chest.2023.09.007. Epub 2023 Sep 16. PMID: 37717936.

Rashedi S, Greason CM, Sadeghipour P, Talasaz AH, O’Donoghue ML, Jimenez D, Monreal M, Anderson CD, Elkind MSV, Kreuziger LMB, Lang IM, Goldhaber SZ, Konstantinides SV, Piazza G, Krumholz HM, Braunwald E, Bikdeli B. Fibrinolytic Agents in Thromboembolic Diseases: Historical Perspectives and Approved Indications. Semin Thromb Hemost. 2024 Jul;50(5):773-789. doi: 10.1055/s-0044-1781451. Epub 2024 Mar 1. PMID: 38428841.

2023

2023

Khairani CD, Bejjani A, Piazza G, Jimenez D, Monreal M, Chatterjee S, Pengo V, Woller SC, Cortes-Hernandez J, Connors JM, Kanthi Y, Krumholz HM, Middeldorp S, Falanga A, Cushman M, Goldhaber SZ, Garcia DA, Bikdeli B. Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients With Antiphospholipid Syndromes: Meta-Analysis of Randomized Trials. J Am Coll Cardiol. 2023 Jan 3;81(1):16-30. doi: 10.1016/j.jacc.2022.10.008. Epub 2022 Oct 31. PMID: 36328154; PMCID: PMC9812926.

Vaduganathan M, Bikdeli B. Closer to FREEDOM From Uncertainty. J Am Coll Cardiol. 2023 May 9;81(18):1763-1765. doi: 10.1016/j.jacc.2023.03.407. PMID: 37137585; PMCID: PMC10150780.

Bertoletti L, Madridano O, Jiménez D, Muriel A, Bikdeli B, Ay C, Trujillo-Santos J, Bosevski M, Sigüenza P, Monreal M. Cancer-Associated Thrombosis: Trends in Clinical Features, Treatment, and Outcomes From 2001 to 2020. JACC CardioOncol. 2023 Nov 15;5(6):758-772. doi: 10.1016/j.jaccao.2023.09.003. PMID: 38205016; PMCID: PMC10774792.

Tritschler T, Sadeghipour P, Bikdeli B. Subgroup analysis in randomized controlled trials: Useful or misleading? Thromb Res. 2023 Dec;232:160-162. doi: 10.1016/j.thromres.2022.10.009. Epub 2022 Oct 18. PMID: 36357215.

Bikdeli B, Erlinge D, Valgimigli M, Kastrati A, Han Y, Steg PG, Stables RH, Mehran R, James SK, Frigoli E, Goldstein P, Li Y, Shahzad A, Schüpke S, Mehdipoor G, Chen S, Redfors B, Crowley A, Zhou Z, Stone GW. Bivalirudin Versus Heparin During PCI in NSTEMI: Individual Patient Data Meta-Analysis of Large Randomized Trials. Circulation. 2023 Oct 17;148(16):1207-1219. doi: 10.1161/CIRCULATIONAHA.123.063946. Epub 2023 Sep 25. PMID: 37746717.

2022

2022

Ortega-Paz L, Talasaz AH, Sadeghipour P, Potpara TS, Aronow HD, Jara-Palomares L, Sholzberg M, Angiolillo DJ, Lip GYH, Bikdeli B. COVID-19-Associated Pulmonary Embolism: Review of the Pathophysiology, Epidemiology, Prevention, Diagnosis, and Treatment. Semin Thromb Hemost. 2023 Nov;49(8):816-832. doi: 10.1055/s-0042-1757634. Epub 2022 Oct 12. PMID: 36223804.

Sadeghipour P, Jenab Y, Moosavi J, Hosseini K, Mohebbi B, Hosseinsabet A, Chatterjee S, Pouraliakbar H, Shirani S, Shishehbor MH, Alizadehasl A, Farrashi M, Rezvani MA, Rafiee F, Jalali A, Rashedi S, Shafe O, Giri J, Monreal M, Jimenez D, Lang I, Maleki M, Goldhaber SZ, Krumholz HM, Piazza G, Bikdeli B. Catheter-Directed Thrombolysis vs Anticoagulation in Patients With Acute Intermediate-High-risk Pulmonary Embolism: The CANARY Randomized Clinical Trial. JAMA Cardiol. 2022 Dec 1;7(12):1189-1197. doi: 10.1001/jamacardio.2022.3591. PMID: 36260302; PMCID: PMC9582964.

2021

2021

Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, Cook JR, Nordvig AS, Shalev D, Sehrawat TS, Ahluwalia N, Bikdeli B, Dietz D, Der-Nigoghossian C, Liyanage-Don N, Rosner GF, Bernstein EJ, Mohan S, Beckley AA, Seres DS, Choueiri TK, Uriel N, Ausiello JC, Accili D, Freedberg DE, Baldwin M, Schwartz A, Brodie D, Garcia CK, Elkind MSV, Connors JM, Bilezikian JP, Landry DW, Wan EY. Post-acute COVID-19 syndrome. Nat Med. 2021 Apr;27(4):601-615. doi: 10.1038/s41591-021-01283-z. Epub 2021 Mar 22. PMID: 33753937; PMCID: PMC8893149.

Jiménez D, Rodríguez C, Monreal M, Bikdeli B. Response. Chest. 2021 Jun;159(6):2513. doi: 10.1016/j.chest.2021.01.024. PMID: 34099142.

Jiménez D, Agustí A, Tabernero E, Jara-Palomares L, Hernando A, Ruiz-Artacho P, Pérez-Peñate G, Rivas-Guerrero A, Rodríguez-Nieto MJ, Ballaz A, Agüero R, Jiménez S, Calle-Rubio M, López-Reyes R, Marcos-Rodríguez P, Barrios D, Rodríguez C, Muriel A, Bertoletti L, Couturaud F, Huisman M, Lobo JL, Yusen RD, Bikdeli B, Monreal M, Otero R; SLICE Trial Group. Effect of a Pulmonary Embolism Diagnostic Strategy on Clinical Outcomes in Patients Hospitalized for COPD Exacerbation: A Randomized Clinical Trial. JAMA. 2021 Oct 5;326(13):1277-1285. doi: 10.1001/jama.2021.14846. PMID: 34609451; PMCID: PMC8493436.

Monreal M, Jiménez D, Bikdeli B. RIETE Registry: Past, Present and Future. Arch Bronconeumol. 2022 Mar;58(3):205-207. English, Spanish. doi: 10.1016/j.arbres.2021.06.010. Epub 2021 Jun 24. PMID: 35312608.

INSPIRATION Investigators; Sadeghipour P, Talasaz AH, Rashidi F, Sharif-Kashani B, Beigmohammadi MT, Farrokhpour M, Sezavar SH, Payandemehr P, Dabbagh A, Moghadam KG, Jamalkhani S, Khalili H, Yadollahzadeh M, Riahi T, Rezaeifar P, Tahamtan O, Matin S, Abedini A, Lookzadeh S, Rahmani H, Zoghi E, Mohammadi K, Sadeghipour P, Abri H, Tabrizi S, Mousavian SM, Shahmirzaei S, Bakhshandeh H, Amin A, Rafiee F, Baghizadeh E, Mohebbi B, Parhizgar SE, Aliannejad R, Eslami V, Kashefizadeh A, Kakavand H, Hosseini SH, Shafaghi S, Ghazi SF, Najafi A, Jimenez D, Gupta A, Madhavan MV, Sethi SS, Parikh SA, Monreal M, Hadavand N, Hajighasemi A, Maleki M, Sadeghian S, Piazza G, Kirtane AJ, Van Tassell BW, Dobesh PP, Stone GW, Lip GYH, Krumholz HM, Goldhaber SZ, Bikdeli B. Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial. JAMA. 2021 Apr 27;325(16):1620-1630. doi: 10.1001/jama.2021.4152. PMID: 33734299; PMCID: PMC7974835.

2020

2020

Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, Bikdeli B, Ahluwalia N, Ausiello JC, Wan EY, Freedberg DE, Kirtane AJ, Parikh SA, Maurer MS, Nordvig AS, Accili D, Bathon JM, Mohan S, Bauer KA, Leon MB, Krumholz HM, Uriel N, Mehra MR, Elkind MSV, Stone GW, Schwartz A, Ho DD, Bilezikian JP, Landry DW. Extrapulmonary manifestations of COVID-19. Nat Med. 2020 Jul;26(7):1017-1032. doi: 10.1038/s41591-020-0968-3. Epub 2020 Jul 10. PMID: 32651579.

Mellado M, Trujillo-Santos J, Bikdeli B, Jiménez D, Núñez MJ, Ellis M, Marchena PJ, Vela JR, Clara A, Moustafa F, Monreal M; RIETE Investigators. Correction to: Vena cava filters in patients presenting with major bleeding during anticoagulation for venous thromboembolism. Intern Emerg Med. 2020 Oct;15(7):1357. doi: 10.1007/s11739-019-02242-w. Erratum for: Intern Emerg Med. 2019 Oct;14(7):1101-1112. doi: 10.1007/s11739-019-02077-5. PMID: 31776841.

Hashemi A, Madhavan MV, Bikdeli B. Pharmacotherapy for Prevention and Management of Thrombosis in COVID-19. Semin Thromb Hemost. 2020 Oct;46(7):789-795. doi: 10.1055/s-0040-1714273. Epub 2020 Aug 20. PMID: 32820478; PMCID: PMC7645828.

Bikdeli B, Carrier M, Bates SM. Subsegmental pulmonary embolism: May not be a killer but indicates significant risk. Thromb Res. 2020 Jan;185:180-182. doi: 10.1016/j.thromres.2019.11.018. Epub 2019 Nov 19. PMID: 31796210.

Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Biondi-Zoccai G, Brown TS, Der Nigoghossian C, Zidar DA, Haythe J, Brodie D, Beckman JA, Kirtane AJ, Stone GW, Krumholz HM, Parikh SA. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic. J Am Coll Cardiol. 2020 May 12;75(18):2352-2371. doi: 10.1016/j.jacc.2020.03.031. Epub 2020 Mar 19. PMID: 32201335; PMCID: PMC7198856.